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|Home >> Research >> POTS Antibodies Research Fund |
Dysautonomia International POTS Antibodies Research Fund
|Dysautonomia International created the POTS Antibodies Research Fund in early 2014 to create a dedicated stream of funding set aside for POTS autoimmunity research. This is in addition to other POTS research that the organization funds. To date, the POTS Antibodies Research Fund has supported three projects, with a fourth ready to launch July 2014 if we can raise another $25,000.
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| || Press Coverage
News9 - Medical Minute: POTS
Vanderbilt Research News
University of Oklahoma Campus News
KFOR - Oklahoma City
Projects Funded To Date:
July 2014 - Vanderbilt University & University of Oklahoma- Adrenergic Antibodies
In July of 2014, we teamed up with researchers at Vanderbilt University and the University of Oklahoma to further investigate the role of adrenergic antibodies in individuals diagnosed with POTS. Rather than waiting for patients to visit research labs one at a time, we sped up the research process by about two years by inviting Vanderbilt's researchers to collect serum from volunteers at our annual conference and the samples were sent to Oklahoma for testing. Over 180 patients and healthy controls participated. Thanks to hundreds of individuals, families, businesses and organizations that donated, we reached our initial goal of raising $50,000 to fund this project in two months.
In a prior study, Autoimmune Basis for Postural Tachycardia Syndrome, published in the Journal of the American Heart Association on February 25, 2014, University of Oklahoma and Vanderbilt University researchers found adrenergic receptor antibodies in all 14 POTS patients that participated in the study. The researchers found evidence that these antibodies may cause the abnormal blood pressure and tachycardia seen in POTS. These same antibodies were previously found in individuals with Orthostatic Hypotension. You can find a plain English explanation of this research on the Dysautonomia Dispatch blog.
July 2014 - UT Southwestern - Ganglionic Acetylcholine Receptor Antibodies
Vanderbilt's researchers collected enough serum from the 2014 conference study to send a small amount of serum from each study volunteer to Dr. Steven Vernino's neuroimmunology lab at the University of Texas Southwestern Medical Center to test for another antibody of interest, ganglionic acetylcholine receptor antibodies (g-AChR). Dr. Vernino is the world's foremost expert on g-AChR antibodies. These antibodies have previously been described in small numbers of POTS patients. Dysautonomia International supported the specimen collection through the earlier grant to Vanderbilt, and Dr. Vernino generously donated his lab resources and staff time to conduct this study. He presented his findings at the American Academy of Neurology meeting in April 2015. We will post details here soon.
January 2015 - University of Oklahoma - Meghan's Hope POTS Research Fellowship
Researchers at the University of Oklahoma continue to pursue lab work related to alpha and beta adrenergic antibodies in POTS. Thanks to a generous private donor, by early 2015 we raised an additional $200,000 to support their efforts to develop a diagnostic blood test and potential drug therapies targeting adrenergic antibodies. The Fellowship has been named after the daughter of the donor, Meghan, a young woman battling POTS.
July 2015 - Mayo Clinic - Mayo Labs Autoimmune Dysautonomia Panel & Thyroid Antibodies
Our fourth POTS Antibodies Fund study will occur during the 2015 Dysautonomia International's Conference, being held in Washington, DC from July 17-20th. Mayo Clinic researchers will be conducting serum from 100+ POTS patients looking for neural and thyroid antibodies in POTS patients. A smaller prior study found one or more of these antibodies in 35% of POTS patients. Please help us raise $25,000 to fund this project.
Other ways to help support this important research:
Create an Online Personal Fundraising Page
You can create a FirstGiving personalized fundraising page and ask your friends and family to donate to the POTS Antibodies Research Fund. Simply visit the Dysautonomia International FirstGiving page to get started. You can view a sample FirstGiving page. Be sure to let your donors know why the POTS Antibodies Fund is important to you.
Host a Fundraiser
Hosting a fundraiser is a great way to raise awareness and raise money, like a Cupcakes for a Cure bake sale or a Dress Down Day for Dysautonomia Research at your school or office.
Employer Matching Gifts
Ask your employer if they will contribute matching funds to charities that you donate to. This is great way to double your donation to the POTS Antibodies Research Fund.
Donate by Check
Print out this Donation Form and follow the instructions on the form to mail in your donation check. If you write "POTS Antibodies Research Fund" in the memo line of your check your donation will go directly to the Fund.